Still recovering from a heart transplant, a retired FBI profiler returns to service when his own blood analysis offers clues to the identity of a serial killer.

A college professor wakes up to find his wife has not returned home, then struggles to understand her disappearance.

Beatrice Prior and Tobias Eaton venture into the world outside of the fence and are taken into protective custody by a mysterious agency known as the Bureau of Genetic Welfare.

20 years since their first adventure, Lloyd and Harry go on a road trip to find Harry’s newly discovered daughter, who was given up for adoption.